Bone Imaging Laboratory University of Calgary

Calgary Vitamin D Study

The Calgary Vitamin D study resulted in several original manuscripts, replies to letter writers about our manuscripts, and development of new techniques that were possible because of the study (but not directly related to vitamin D).

Journal Publications

Effect of High-Dose Vitamin D Supplementation on Volumetric Bone Density and Bone Strength
Effect of High-Dose Vitamin D Supplementation on Volumetric Bone Density and Bone Strength
Lauren A. Burt, Emma O. Billington, Marianne S. Rose, Duncan A. Raymond, David A. Hanley, Steven K. Boyd
JAMA  ·  27 Aug 2019  ·  doi:10.1001/jama.2019.11889
Measurements of the Vitamin D Metabolome in the Calgary Vitamin D Study: Relationship of Vitamin D Metabolites to Bone Loss
Lauren A. Burt, Martin Kaufmann, Marianne S. Rose, Glenville Jones, Emma O. Billington, Steven K. Boyd, David A. Hanley
Journal of Bone and Mineral Research  ·  17 Jul 2023  ·  doi:10.1002/jbmr.4876
Methods and procedures for: A randomized double-blind study investigating dose-dependent longitudinal effects of vitamin D supplementation on bone health
Lauren A. Burt, Sharon Gaudet, Michelle Kan, Marianne S. Rose, Emma O. Billington, Steven K. Boyd, David A. Hanley
Contemporary Clinical Trials  ·  01 Apr 2018  ·  doi:10.1016/j.cct.2018.02.009
Postural Balance Effects Associated with 400, 4000 or 10,000 IU Vitamin D3 Daily for Three Years: A Secondary Analysis of a Randomized Clinical Trial
Lauren A. Burt, Leigh Gabel, Emma O. Billington, David A. Hanley, Steven K. Boyd
Nutrients  ·  19 Feb 2020  ·  doi:10.3390/nu12020527
Safety of High-Dose Vitamin D Supplementation: Secondary Analysis of a Randomized Controlled Trial
Emma O Billington, Lauren A Burt, Marianne S Rose, Erin M Davison, Sharon Gaudet, Michelle Kan, Steven K Boyd, David A Hanley
The Journal of Clinical Endocrinology & Metabolism  ·  20 Nov 2019  ·  doi:10.1210/clinem/dgz212
Effect of high-dose vitamin D supplementation on peripheral arterial calcification: secondary analysis of a randomized controlled trial
E. O. Billington, L. A. Burt, R. Plett, M. S. Rose, S.K. Boyd, D. A. Hanley
Osteoporosis International  ·  15 Jun 2020  ·  doi:10.1007/s00198-020-05500-2
Reply to Burt LA, et al.: Adverse Effects of High-Dose Vitamin D Supplementation on Volumetric Bone Density Are Greater in Females Than Males
Lauren A Burt, Emma O Billington, Marianne S Rose, Richard Kremer, David A Hanley, Steven K Boyd
Journal of Bone and Mineral Research  ·  01 Dec 2020  ·  doi:10.1002/jbmr.4251
Response to High‐Dose Vitamin D Supplementation Is Specific to Imaging Modality and Skeletal Site
Lauren A Burt, Leigh Gabel, Emma O Billington, David A Hanley, Steven K Boyd
JBMR Plus  ·  08 Mar 2022  ·  doi:10.1002/jbm4.10615

Reply Letters

High-Dose Vitamin D Supplementation and Bone Health—Reply
David A. Hanley, Lauren A. Burt, Steven K. Boyd
JAMA  ·  07 Jan 2020  ·  doi:10.1001/jama.2019.18153
Reply to Effects of High-Dose Vitamin D Supplementation on Bone Fragility
Lauren A Burt, Emma O Billington, Marianne S Rose, Richard Kremer, David A Hanley, Steven K Boyd
Journal of Bone and Mineral Research  ·  23 Oct 2020  ·  doi:10.1002/jbmr.4190
Reply to Vitamin D Supplements: Is Bone Loss by HR-pQCT Really Negative?
Lauren A Burt, Emma O Billington, Marianne S Rose, Richard Kremer, David A Hanley, Steven K Boyd
Journal of Bone and Mineral Research  ·  01 Dec 2020  ·  doi:10.1002/jbmr.4247
Reply to Burt LA, et al.: Adverse Effects of High-Dose Vitamin D Supplementation on Volumetric Bone Density Are Greater in Females Than Males
Lauren A Burt, Emma O Billington, Marianne S Rose, Richard Kremer, David A Hanley, Steven K Boyd
Journal of Bone and Mineral Research  ·  01 Dec 2020  ·  doi:10.1002/jbmr.4251
Longitudinal bone microarchitectural changes are best detected using image registration
T.D. Kemp, C.M.J. de Bakker, L. Gabel, D.A. Hanley, E.O. Billington, L.A. Burt, S.K. Boyd
Osteoporosis International  ·  19 May 2020  ·  doi:10.1007/s00198-020-05449-2
Using 3D image registration to maximize the reproducibility of longitudinal bone strength assessment by HR-pQCT and finite element analysis
R. M. Plett, T. D. Kemp, L. A. Burt, E. O. Billington, D. A. Hanley, S. K. Boyd
Osteoporosis International  ·  24 Feb 2021  ·  doi:10.1007/s00198-021-05896-5

About the Study

This study was made possible by Pure North S’Energy Foundation through an investigator-initiated research grant proposal.

Its success was in large part due to the dedicated team at the University of Calgary who were involved in all aspects of the study from original design to implementation. A special thanks to our staff including Sharon Gaudet, Jane Allan, Michelle Kan, Anne Cooke, Stephanie Kwong, Jolene Allan, Duncan Raymond and Amanda Sellar-Bouchard.

Most of all, we want to thank the people who volunteered for this study and who dedicated three years of their lives to taking daily doses of vitamin D and making regular trips to our facility at the McCaig Institute for Bone and Joint Health for their study visits.

Although data collection is now complete, we continue to work on the enormous volume of data that was collected. As we publish further findings, we will add them to the list on this page.

Last updated in October, 2024.